7-Dehydrocholesterol Reductase (DHCR7) Antibody
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Description
7-Dehydrocholesterol Reductase (DHCR7) Antibody is a Rabbit Polyclonal antibody against 7-Dehydrocholesterol Reductase (DHCR7).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 7-Dehydrocholesterol Reductase (DHCR7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UBM7 |
| Gene ID | 1717 |
| Background | Antibody anti-DHCR7 |
| Status | RUO |
Descripción
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7-Dehydrocholesterol Reductase (DHCR7) Antibody
DHCR7 Antibody is a Rabbit Polyclonal Antibody against DHCR7.
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7-Dehydrocholesterol Reductase (DHCR7) Antibody
This gene encodes an enzyme that removes the C (7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS) ; a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.
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