14-3-3 Protein Epsilon (YWHAE) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
14-3-3 Protein Epsilon (YWHAE) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013879
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against 14-3-3 epsilon protein. Immunogen region is C-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 14-3-3 Protein Epsilon (YWHAE) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P62258 |
| Alias | YWHAE, 14-3-3E, HEL2, KCIP-1, MDCR, MDS,14-3-3 epsilon |
| Background | Antibody anti-YWHAE |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
YWHAE, another member of the 14-3-3 family, functions as an adaptor protein that regulates protein-protein interactions, cellular localization, and stability of signaling molecules. By binding to phosphorylated targets, YWHAE modulates pathways such as MAPK, Wnt/β-catenin, and PI3K/Akt, controlling processes like cell proliferation, apoptosis, and cytoskeletal dynamics. It is highly expressed in neuronal tissues, where it plays critical roles in brain development, axon guidance, and synaptic function. YWHAE also regulates the DNA damage response and tumor suppression pathways by interacting with proteins like p53 and Chk1. Dysregulation of YWHAE is linked to developmental disorders, including Miller-Dieker syndrome and neurodevelopmental abnormalities, as well as cancers where it promotes tumor progression and metastasis. Knockout models exhibit defects in brain development, impaired cell migration, and increased susceptibility to stress, emphasizing its role in neurodevelopment, cell signaling, and maintaining cellular integrity.
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