Family main features
Peroxidasin (PXDN) is a unique extracellular matrix enzyme belonging to the peroxidase family, which includes well-known enzymes like myeloperoxidase and thyroid peroxidase. This enzyme plays a crucial role in various biological processes, primarily related to the formation and maintenance of extracellular matrices, tissue development, and oxidative stress responses. PXDN is encoded by the PXDN gene located on chromosome 2p25 in humans. The importance of PXDN is highlighted by its involvement in several physiological and pathological conditions, including basement membrane formation, angiogenesis, wound healing, and certain diseases like cancer and fibrosis.
The PXDN protein consists of multiple domains that contribute to its multifunctional nature:
The combination of these domains enables PXDN to function as a versatile enzyme with both structural and catalytic roles in the extracellular environment.
PXDN is a member of the heme peroxidase family, which includes other peroxidases such as:
PXDN is distinct among these peroxidases due to its extracellular matrix localization and multifunctional roles in tissue structure and development.
PXDN performs several crucial functions in the body:
Dysregulation of PXDN is associated with several diseases and conditions:
Peroxidasin (PXDN) is a multifunctional extracellular matrix enzyme crucial for collagen IV crosslinking, angiogenesis, oxidative stress response, and wound healing. Structurally, it comprises a peroxidase domain, LRR domain, Ig domains, and a vWF type D domain, allowing it to perform diverse roles in the extracellular environment. Dysregulation of PXDN is linked to several clinical conditions, including cancer, fibrosis, congenital disorders, and cardiovascular diseases. Understanding the functions and regulation of PXDN is essential for developing therapeutic strategies for these conditions. Further research into PXDN's mechanisms and interactions will provide deeper insights into its role in health and disease.
peroxidasin (PXDN)
PXN,VPO,MG50,PRG2,ASGD7,COPOA,D2S448,D2S448E,hsPxd01,VPO1,Peroxidasin 1,Vascular peroxidase 1,p53-responsive gene 2 protein,Melanoma-associated antigen MG50,Peroxidasin homolog
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con PXDN - peroxidasin
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 13 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | PXDN | EH1098 | Human PXDN(Peroxidasin homolog) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | Q92626 | RUO | ||
Abbexa | PXDN | abx152710 | Human Peroxidasin Homolog (PXDN) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | PXDN | abx496021 | Human Peroxidasin Homolog (PXDN) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.062 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | PXDN | abx514480 | Mouse Peroxidasin homolog (PXDN) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 1.56 ng/ml - 100 ng/ml | 0.53 ng/ml | 687.5 | 96 tests | Q3UQ28 | RUO |
Abbexa | PXDN | abx258961 | Rat Peroxidasin Homolog (PXDN) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 737.5 | 96 tests | RUO | |
Abbexa | PXDN | abx496575 | Rat Peroxidasin Homolog (PXDN) CLIA Kit | Rat | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.056 ng/ml | 868.75 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | PXDN | abx101905 | Peroxidasin Homolog (PXDN) Antibody | Human | Polyclonal | Rabbit | Peroxidasin Homolog (PXDN) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q92626 | RUO | |
Abbexa | PXDN | abx101906 | Peroxidasin Homolog (PXDN) Antibody | Human | Polyclonal | Rabbit | Peroxidasin Homolog (PXDN) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q92626 | RUO | |
Abbexa | PXDN | abx370335 | Peroxidasin Homolog (PXDN) Antibody Pair | Human | Peroxidasin Homolog (PXDN) | ELISA | 1600 | 5 × 96 tests | RUO | |||||
Abbexa | PXDN | abx240259 | Peroxidasin Homolog (PXDN) Antibody | Human | Polyclonal | Rabbit | Peroxidasin Homolog (PXDN) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q92626 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | PXDN | P1624 | Recombinant Human PXDN | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | Q92626 | RUO | ||
Abbexa | PXDN | abx068474 | Human Peroxidasin Homolog (PXDN) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q92626 | RUO |
Abbexa | PXDN | abx068473 | Human Peroxidasin Homolog (PXDN) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q92626 | RUO |
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