NR2F - nuclear receptor subfamily 2 group F member| Elisa - Clia - Antibody - Protein

Background

The NR2F family, part of the nuclear receptor subfamily 2 group F, encompasses the NR2F1 (COUP-TF1) and NR2F2 (COUP-TF2) receptors. These nuclear receptors are crucial for various developmental processes, including organogenesis, angiogenesis, and cellular differentiation. They are widely expressed in multiple tissues during embryonic development and play a significant role in regulating gene expression involved in these processes.

Protein Structure

NR2F proteins have a characteristic structure common to nuclear receptors:

• N-terminal Domain (NTD): This domain is highly variable and plays a role in transcriptional regulation.
• DNA-binding Domain (DBD): Contains two zinc finger motifs essential for binding to specific DNA sequences called response elements.
• Hinge Region: Provides flexibility to the receptor and aids in its transport to the nucleus.
• Ligand-binding Domain (LBD): Binds to potential ligands, though NR2F proteins are considered orphan receptors with no known endogenous ligands. This domain also facilitates dimerization and interaction with co-regulatory proteins.

Classification and Subtypes

NR2F receptors are classified within the nuclear receptor superfamily, subfamily 2, group F. The main members include:

• NR2F1 (COUP-TF1): Involved in neurogenesis, angiogenesis, and metabolism.
• NR2F2 (COUP-TF2): Plays a role in cardiac development, angiogenesis, and metabolism.

Function and Biological Significance

NR2F receptors function as transcription factors, influencing a variety of biological processes:

• Developmental Regulation: They are crucial in early development stages, including neural tube formation, angiogenesis, and heart development.
• Metabolism: NR2F receptors regulate genes involved in lipid metabolism and energy homeostasis.
• Cell Differentiation: They play a role in the differentiation of various cell types, including neurons and muscle cells.

Clinical Issues

• Developmental Disorders: Mutations or dysregulation of NR2F receptors can lead to congenital anomalies, including defects in heart and neural development.
• Cancer: Abnormal expression of NR2F1 and NR2F2 has been linked to various cancers, where they may influence tumor growth and metastasis.
• Metabolic Diseases: Dysregulation of NR2F receptors can contribute to metabolic disorders such as obesity and diabetes.

Summary

NR2F receptors, encompassing NR2F1 and NR2F2, are orphan nuclear receptors with vital roles in development, metabolism, and cell differentiation. These receptors act as transcription factors, regulating the expression of genes essential for organogenesis, angiogenesis, and metabolic processes. Understanding the functions and regulatory mechanisms of NR2F receptors can provide insights into their involvement in developmental disorders, cancer, and metabolic diseases, highlighting their potential as therapeutic targets.