Family main features
The GPBA receptor, also known as GPBAR1 or TGR5 (Takeda G protein-coupled bile acid receptor 1), is a G protein-coupled receptor (GPCR) primarily expressed in the liver, gallbladder, intestines, and other tissues. It serves as a key regulator of bile acid signaling and plays diverse roles in metabolic regulation, energy homeostasis, and inflammatory responses.
GPBAR1 shares the characteristic seven-transmembrane domain structure typical of GPCRs. It consists of an extracellular N-terminus and an intracellular C-terminus, which interact with intracellular signaling molecules upon ligand binding. GPBAR1 activation leads to downstream signaling events mediated by heterotrimeric G proteins.
The primary endogenous ligands for GPBAR1 are bile acids, which are amphipathic molecules synthesized from cholesterol and secreted into the bile by hepatocytes. Bile acids serve multiple physiological functions, including facilitating fat digestion and absorption, regulating cholesterol metabolism, and acting as signaling molecules through interactions with GPBAR1 and other receptors.
GPBAR1 signaling exerts diverse effects on various tissues and organ systems:
Dysregulation of GPBAR1 signaling is associated with various pathological conditions:
Given its roles in metabolic regulation, inflammatory responses, and gastrointestinal function, GPBAR1 represents a promising target for therapeutic intervention. Pharmacological modulation of GPBAR1 activity, either through agonists or antagonists, holds potential for the treatment of metabolic disorders, inflammatory diseases, and gastrointestinal disorders.
G-Protein Coupled Bile Acid Receptor 1 (GPBAR1)
GPBAR1,BG37,GPCR19,GPR131,M-BAR,TGR5,GPBAR1,G protein-coupled bile acid receptor 1,membrane-type receptor for bile acids
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (ELISA Kits, Primary Antibodies) relacionados con GPBAR1 - G-Protein Coupled Bile Acid Receptor 1
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 13 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | GPBAR1 | abx555795 | Cow G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q862A9 | RUO | ||
Abbexa | GPBAR1 | abx555407 | Human G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 687.5 | 96 tests | Q8TDU6 | RUO | |
FineTest | GPBAR1 | EM1917 | Mouse Gpbar1 (G-protein coupled bile acid receptor 1) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q80SS6 | RUO | ||
Abbexa | GPBAR1 | abx556098 | Mouse G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.068 ng/ml | 687.5 | 96 tests | Q80SS6 | RUO |
FineTest | GPBAR1 | ER6537 | Rat Gpbar1(G-protein coupled bile acid receptor 1) ELISA Kit | rat | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q80T02 | RUO | ||
Abbexa | GPBAR1 | abx556238 | Rat G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | < 0.37 ng/ml | 687.5 | 96 tests | Q80T02 | RUO |
Abbexa | GPBAR1 | abx585513 | Rat G Protein Coupled Receptor 131 (GPR131) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.625 ng/ml - 40 ng/ml | < 0.26 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | GPBAR1 | abx391365 | Low Sample Volume Rat G Protein Coupled Receptor 131 (GPR131) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.625 ng/ml - 40 ng/ml | < 0.26 ng/ml | 862.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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Abbexa | GPBAR1 | abx322810 | G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) Antibody | Human | Polyclonal | Rabbit | G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) | Unconjugated | ELISA, IF/ICC | 187.5 | 50 µg | Q8TDU6 | RUO | |
Abbexa | GPBAR1 | abx335844 | G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) Antibody (HRP) | Human | Polyclonal | Rabbit | G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) | HRP | ELISA | 162.5 | 20 µg | Q8TDU6 | RUO | |
Abbexa | GPBAR1 | abx335845 | G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) Antibody (FITC) | Human | Polyclonal | Rabbit | G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) | FITC | 162.5 | 20 µg | Q8TDU6 | RUO | ||
Abbexa | GPBAR1 | abx335846 | G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) Antibody (Biotin) | Human | Polyclonal | Rabbit | G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) | Biotin | ELISA | 162.5 | 20 µg | Q8TDU6 | RUO | |
Abbexa | GPBAR1 | abx338732 | G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) Antibody | Human | Polyclonal | Rabbit | G-Protein Coupled Bile Acid Receptor 1 (GPBAR1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | Q8TDU6 | RUO |
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