Family main features
Dynein axonemal intermediate chain (DNAI) proteins are critical components of the dynein complex, which is essential for the movement of cilia and flagella. The dynein complex is a large multi-subunit motor protein that converts chemical energy from ATP hydrolysis into mechanical work, enabling the sliding of microtubules within cilia and flagella. This movement is crucial for various cellular processes, including cell motility, fluid movement across epithelial surfaces, and sensory functions. Defects in DNAI proteins are often associated with primary ciliary dyskinesia (PCD), a genetic disorder characterized by chronic respiratory tract infections, reduced fertility, and abnormal organ positioning due to impaired ciliary function.
DNAI proteins are characterized by their intermediate chain structure within the dynein complex. These proteins typically have several conserved domains that facilitate their interaction with other dynein subunits and regulatory proteins:
The DNAI family includes several members, each with specific roles in different types of cilia and flagella:
DNAI proteins play a pivotal role in the function of the dynein motor complex, which is critical for:
Dynein axonemal intermediate chain proteins are crucial components of the dynein motor complex, playing essential roles in the movement and function of cilia and flagella. Their importance is underscored by their involvement in critical physiological processes such as respiratory health, sensory perception, and reproductive function. Mutations in DNAI genes are linked to primary ciliary dyskinesia, highlighting the clinical significance of these proteins. Ongoing research aims to further elucidate the precise mechanisms of DNAI protein function and develop targeted therapies for conditions resulting from their dysfunction.
dynein axonemal intermediate chain 1 (DNAI1)
PCD,DIC1,ICS1,oda6,CILD1,Axonemal dynein intermediate chain 1
dynein axonemal intermediate chain 2 (DNAI2)
DIC2,oda6,CILD9,Axonemal dynein intermediate chain 2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con DNAI - dynein axonemal intermediate chain
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 19 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | DNAI1 | abx386922 | Human Dynein Intermediate Chain 1, Axonemal (DNAI1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 9.5 pg/ml | 687.5 | 96 tests | Q9UI46 | RUO |
Abbexa | DNAI2 | abx386923 | Human Dynein Intermediate Chain 2, Axonemal (DNAI2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q9GZS0 | RUO |
Abbexa | DNAI1 | abx510657 | Mouse Dynein intermediate chain 1, axonemal (DNAI1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8C0M8 | RUO | |
Abbexa | DNAI2 | abx389118 | Mouse Dynein Intermediate Chain 2, Axonemal (DNAI2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | A2AC93 | RUO |
Abbexa | DNAI1 | abx510658 | Rat Dynein Intermediate Chain 1, Axonemal (DNAI1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q5XIL8 | RUO | |
Abbexa | DNAI2 | abx391261 | Rat Dynein Intermediate Chain 2, Axonemal (DNAI2) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | Q66HC9 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | DNAI1 | FNab02437 | anti- DNAI1 antibody | human | polyclonal | Rabbit | dynein, axonemal, intermediate chain 1 | IgG | Unconjugated | ELISA, WB | 100µg | Q9UI46 | RUO | |
FineTest | DNAI2 | FNab02438 | anti- DNAI2 antibody | human | polyclonal | Rabbit | dynein, axonemal, intermediate chain 2 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q9GZS0 | RUO | |
Abbexa | DNAI1 | abx029047 | Dynein Intermediate Chain 1, Axonemal (DNAI1) Antibody | Human | Polyclonal | Rabbit | Dynein Intermediate Chain 1, Axonemal (DNAI1) | Unconjugated | ELISA, WB | 250 | 80 µl | Q9UI46 | RUO | |
Abbexa | DNAI1 | abx125764 | Dynein Intermediate Chain 1, Axonemal (DNAI1) Antibody | Human | Polyclonal | Rabbit | Dynein Intermediate Chain 1, Axonemal (DNAI1) | Unconjugated | WB | 175 | 20 µl | Q9UI46 | RUO | |
Abbexa | DNAI1 | abx112196 | Dynein Intermediate Chain 1, Axonemal (DNAI1) Antibody | Human | Polyclonal | Rabbit | Dynein Intermediate Chain 1, Axonemal (DNAI1) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q9UI46 | RUO | |
Abbexa | DNAI1 | abx232437 | Dynein Intermediate Chain 1, Axonemal (DNAI1) Antibody | Human | Polyclonal | Rabbit | Dynein Intermediate Chain 1, Axonemal (DNAI1) | Unconjugated | ELISA, WB | 350 | 100 µg | Q9UI46 | RUO | |
Abbexa | DNAI1 | abx327547 | Dynein Intermediate Chain 1, Axonemal (DNAI1) Antibody | Human | Polyclonal | Rabbit | Dynein Intermediate Chain 1, Axonemal (DNAI1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q9UI46 | RUO | |
Abbexa | DNAI2 | abx031421 | Dynein Intermediate Chain 2, Axonemal (DNAI2) Antibody | Human | Polyclonal | Rabbit | Dynein Intermediate Chain 2, Axonemal (DNAI2) | Unconjugated | ELISA, WB | 250 | 80 µl | Q9GZS0 | RUO | |
Abbexa | DNAI2 | abx122579 | Dynein Intermediate Chain 2, Axonemal (DNAI2) Antibody | Human | Polyclonal | Rabbit | Dynein Intermediate Chain 2, Axonemal (DNAI2) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | DNAI2 | abx119104 | Dynein Intermediate Chain 2, Axonemal (DNAI2) Antibody | Human | Polyclonal | Rabbit | Dynein Intermediate Chain 2, Axonemal (DNAI2) | Unconjugated | WB | 43.75 | 10 µg | Q9GZS0 | RUO | |
Abbexa | DNAI2 | abx112197 | Dynein Intermediate Chain 2, Axonemal (DNAI2) Antibody | Human | Polyclonal | Rabbit | Dynein Intermediate Chain 2, Axonemal (DNAI2) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q9GZS0 | RUO | |
Abbexa | DNAI2 | abx327322 | Dynein Intermediate Chain 2, Axonemal (DNAI2) Antibody | Human | Polyclonal | Rabbit | Dynein Intermediate Chain 2, Axonemal (DNAI2) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q9GZS0 | RUO | |
Abbexa | DNAI2 | abx232438 | Dynein Intermediate Chain 2, Axonemal (DNAI2) Antibody | Human | Polyclonal | Rabbit | Dynein Intermediate Chain 2, Axonemal (DNAI2) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q9GZS0 | RUO |
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