Family main features
CD48, also known as SLAMF2 (Signaling Lymphocytic Activation Molecule Family Member 2), is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that plays a crucial role in immune cell interactions and signaling. It is part of the immunoglobulin (Ig) superfamily and is broadly expressed on the surface of various hematopoietic cells, including T cells, B cells, NK cells, dendritic cells, and macrophages. CD48 is involved in the regulation of immune responses and has been implicated in various pathological conditions, including infectious diseases, autoimmune disorders, and cancers.
CD48 is a single-chain glycoprotein consisting of 243 amino acids with several distinct structural features:
CD48 belongs to the SLAM (Signaling Lymphocytic Activation Molecule) family, a subgroup of the immunoglobulin superfamily. Other members of this family include:
These molecules are characterized by their roles in immune cell activation, adhesion, and signaling. While there are no known subtypes of CD48, its interactions with other SLAM family members and ligands, such as 2B4 (CD244), significantly influence immune cell behavior.
Immune Cell Activation and Co-Stimulation:
Cytotoxicity and NK Cell Function:
Regulation of Immune Responses:
Pathological Implications:
Autoimmune Diseases:
Cancer:
Infectious Diseases:
CD48 is a GPI-anchored membrane protein of the immunoglobulin superfamily, playing a pivotal role in immune cell interactions and signaling. It is widely expressed on hematopoietic cells and is involved in immune cell activation, co-stimulation, and regulation of immune responses. CD48's interaction with 2B4 (CD244) is crucial for NK cell-mediated cytotoxicity and immune surveillance against tumors and infections. Dysregulation of CD48 expression and function is associated with various pathological conditions, including autoimmune diseases, cancers, and infectious diseases. Understanding the molecular mechanisms of CD48 and its role in immune regulation provides valuable insights for developing targeted therapies for these conditions.
CD48 molecule (CD48)
BCM1,BLAST,Hcd48,mCD48,BLAST1,SLAMF2,MEM-102,B-lymphocyte activation marker,BCM1 surface antigen,Leukocyte antigen MEM-102,SLAM family member 2,Signaling lymphocytic activation molecule 2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con CD48 molecule
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Esta página contiene 48 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CD48 | EH4332 | Human CD48(CD48 antigen) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | P09326 | RUO | ||
Abbexa | CD48 | abx505789 | Human CD48 Antigen / BLAST1 (CD48) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P09326 | RUO | |
Abbexa | CD48 | abx505790 | Mouse CD48 Antigen / BLAST1 (CD48) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P18181 | RUO | ||
Abbexa | CD48 | abx505791 | Rat CD48 Antigen / BLAST1 (CD48) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P10252 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD48 | abx228580 | CD48 Antigen / BLAST1 (CD48) Antibody (PE) | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | IgG1 | PE | FCM | 125 | 20 tests | P09326 | RUO |
Abbexa | CD48 | abx228583 | CD48 Antigen / BLAST1 (CD48) Antibody (PE / Cyanine 5) | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | PE / Cyanine 5 | FCM | 200 | 20 tests | P09326 | RUO | |
Abbexa | CD48 | abx402065 | CD48 antigen (CD48) Antibody | Human | Monoclonal | Rabbit | CD48 antigen (CD48) | Unconjugated | ELISA, WB | 287.5 | 50 µl | P09326 | RUO | |
Abbexa | CD48 | abx228581 | CD48 Antigen / BLAST1 (CD48) Antibody (APC) | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | IgG1 | APC | FCM | 112.5 | 20 tests | P09326 | RUO |
Abbexa | CD48 | abx038016 | CD48 Antigen / BLAST1 (CD48) Antibody | Human | Polyclonal | Rabbit | CD48 Antigen / BLAST1 (CD48) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | CD48 | abx228586 | CD48 Antigen / BLAST1 (CD48) Antibody (PerCP / Cyanine 5.5) | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | IgG1 | PerCP / Cyanine 5.5 | FCM | 200 | 20 tests | P09326 | RUO |
Abbexa | CD48 | abx412697 | CD48 Antigen / BLAST1 (CD48) Antibody (FITC) | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | FITC | FCM | 437.5 | 100 µg | P09326 | RUO | |
Abbexa | CD48 | abx111488 | CD48 Antigen / BLAST1 (CD48) Antibody | Human | Polyclonal | Rabbit | CD48 Antigen / BLAST1 (CD48) | Unconjugated | ELISA | 612.5 | 100 µl | P09326 | RUO | |
Abbexa | CD48 | abx320145 | CD48 Antigen / BLAST1 (CD48) Antibody | Human | Polyclonal | Rabbit | CD48 Antigen / BLAST1 (CD48) | Unconjugated | ELISA, IHC | 237.5 | 50 µl | P09326 | RUO | |
Abbexa | CD48 | abx323667 | CD48 Antigen / BLAST1 (CD48) Antibody | Human | Polyclonal | Rabbit | CD48 Antigen / BLAST1 (CD48) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P09326 | RUO | |
Abbexa | CD48 | abx412700 | CD48 Antigen / BLAST1 (CD48) Antibody (PE) | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | PE | FCM | 487.5 | 100 tests | P09326 | RUO | |
Abbexa | CD48 | abx228579 | CD48 Antigen / BLAST1 (CD48) Antibody (FITC) | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | IgG1 | FITC | FCM | 112.5 | 20 tests | P09326 | RUO |
Abbexa | CD48 | abx412696 | CD48 Antigen / BLAST1 (CD48) Antibody (APC) | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | APC | FCM | 487.5 | 100 tests | P09326 | RUO | |
Abbexa | CD48 | abx412698 | CD48 Antigen / BLAST1 (CD48) Antibody | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | Unconjugated | WB, IHC, IF/ICC, FCM | 462.5 | 200 µg | P09326 | RUO | |
Abbexa | CD48 | abx412699 | CD48 Antigen / BLAST1 (CD48) Antibody | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | Unconjugated | WB, IHC, IF/ICC, FCM | 175 | 25 µg | P09326 | RUO | |
Abbexa | CD48 | abx139295 | CD48 Antigen / BLAST1 (CD48) Antibody (FITC) | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | FITC | FCM | 350 | 100 tests | P09326 | RUO | |
Abbexa | CD48 | abx139294 | CD48 Antigen / BLAST1 (CD48) Antibody (Biotin) | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | Biotin | WB, IHC-P, FCM, IP | 350 | 0.1 mg | P09326 | RUO | |
Abbexa | CD48 | abx139292 | CD48 Antigen / BLAST1 (CD48) Antibody (PE) | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | PE | FCM | 400 | 100 tests | P09326 | RUO | |
Abbexa | CD48 | abx139293 | CD48 Antigen / BLAST1 (CD48) Antibody (APC) | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | APC | FCM | 400 | 100 tests | P09326 | RUO | |
Abbexa | CD48 | abx139291 | CD48 Antigen / BLAST1 (CD48) Antibody | Human | Monoclonal | Mouse | CD48 Antigen / BLAST1 (CD48) | Unconjugated | WB, IHC-P, FCM, IP | 275 | 0.1 mg | P09326 | RUO | |
Abbexa | CD48 | abx322199 | CD48 Antigen / BLAST1 (CD48) Antibody | Human | Polyclonal | Rabbit | CD48 Antigen / BLAST1 (CD48) | Unconjugated | ELISA, WB | 237.5 | 50 µl | P09326 | RUO | |
Abbexa | CD48 | abx341029 | CD48 antigen (CD48) Antibody | Human | Monoclonal | Mouse | CD48 antigen (CD48) | Unconjugated | ELISA, WB, IF/ICC, FCM | 287.5 | 50 µl | P09326 | RUO | |
Abbexa | CD48 | abx341030 | CD48 antigen (CD48) Antibody | Human | Monoclonal | Mouse | CD48 antigen (CD48) | Unconjugated | ELISA, WB, IF/ICC, FCM | 287.5 | 50 µl | P09326 | RUO | |
Abbexa | CD48 | abx211925 | CD48 Antigen / BLAST1 (CD48) Antibody | Human | Polyclonal | Rabbit | CD48 Antigen / BLAST1 (CD48) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P09326 | RUO | |
Abbexa | CD48 | abx211924 | CD48 Antigen / BLAST1 (CD48) Antibody | Human | Polyclonal | Rabbit | CD48 Antigen / BLAST1 (CD48) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P09326 | RUO | |
Abbexa | CD48 | abx228220 | CD48 Antigen / BLAST1 (CD48) Antibody | Mouse | Monoclonal | Hamster | CD48 Antigen / BLAST1 (CD48) | IgG | Unconjugated | IHC, FCM, IP | 62.5 | 25 µg | P18181 | RUO |
Abbexa | CD48 | abx228221 | CD48 Antigen / BLAST1 (CD48) Antibody (Biotin) | Mouse | Monoclonal | Hamster | CD48 Antigen / BLAST1 (CD48) | IgG | Biotin | FCM | 75 | 25 µg | P18181 | RUO |
Abbexa | CD48 | abx415654 | CD48 Antigen / BLAST1 (CD48) Antibody (FITC) | Mouse | Monoclonal | Rat | CD48 Antigen / BLAST1 (CD48) | FITC | FCM | 400 | 100 µg | P18181 | RUO | |
Abbexa | CD48 | abx228219 | CD48 Antigen / BLAST1 (CD48) Antibody | Mouse | Monoclonal | Hamster | CD48 Antigen / BLAST1 (CD48) | IgG | Unconjugated | IHC, FCM, IP | 118.75 | 50 µg | P18181 | RUO |
Abbexa | CD48 | abx228230 | CD48 Antigen / BLAST1 (CD48) Antibody (AF488) | Mouse | Monoclonal | Hamster | CD48 Antigen / BLAST1 (CD48) | AF488 | FCM | 200 | 50 tests | P18181 | RUO | |
Abbexa | CD48 | abx415655 | CD48 Antigen / BLAST1 (CD48) Antibody | Mouse | Monoclonal | Rat | CD48 Antigen / BLAST1 (CD48) | Unconjugated | FCM | 462.5 | 250 µg | P18181 | RUO | |
Abbexa | CD48 | abx228229 | CD48 Antigen / BLAST1 (CD48) Antibody (PerCP / Cyanine 5.5) | Mouse | Monoclonal | Hamster | CD48 Antigen / BLAST1 (CD48) | IgG | PerCP / Cyanine 5.5 | FCM | 200 | 50 tests | P18181 | RUO |
Abbexa | CD48 | abx228231 | CD48 Antigen / BLAST1 (CD48) Antibody (AF647) | Mouse | Monoclonal | Hamster | CD48 Antigen / BLAST1 (CD48) | IgG | AF647 | FCM | 200 | 50 tests | P18181 | RUO |
Abbexa | CD48 | abx415656 | CD48 Antigen / BLAST1 (CD48) Antibody | Mouse | Monoclonal | Rat | CD48 Antigen / BLAST1 (CD48) | Unconjugated | FCM | 337.5 | 100 µg | P18181 | RUO | |
Abbexa | CD48 | abx415657 | CD48 Antigen / BLAST1 (CD48) Antibody (PE) | Mouse | Monoclonal | Rat | CD48 Antigen / BLAST1 (CD48) | PE | FCM | 487.5 | 100 tests | P18181 | RUO | |
Abbexa | CD48 | abx228225 | CD48 Antigen / BLAST1 (CD48) Antibody (PerCP) | Mouse | Monoclonal | Hamster | CD48 Antigen / BLAST1 (CD48) | PerCP | FCM | 200 | 50 tests | P18181 | RUO | |
Abbexa | CD48 | abx228224 | CD48 Antigen / BLAST1 (CD48) Antibody (APC) | Mouse | Monoclonal | Hamster | CD48 Antigen / BLAST1 (CD48) | IgG | APC | FCM | 125 | 50 tests | P18181 | RUO |
Abbexa | CD48 | abx228223 | CD48 Antigen / BLAST1 (CD48) Antibody (PE) | Mouse | Monoclonal | Hamster | CD48 Antigen / BLAST1 (CD48) | IgG | PE | FCM | 125 | 50 tests | P18181 | RUO |
Abbexa | CD48 | abx228222 | CD48 Antigen / BLAST1 (CD48) Antibody (FITC) | Mouse | Monoclonal | Hamster | CD48 Antigen / BLAST1 (CD48) | IgG | FITC | FCM | 125 | 50 tests | P18181 | RUO |
Abbexa | CD48 | abx228227 | CD48 Antigen / BLAST1 (CD48) Antibody (PE / Cyanine 7) | Mouse | Monoclonal | Hamster | CD48 Antigen / BLAST1 (CD48) | IgG | PE / Cyanine 7 | FCM | 200 | 50 tests | P18181 | RUO |
Abbexa | CD48 | abx006295 | CD48 Antigen / BLAST1 (CD48) Antibody | Mouse | Polyclonal | Rabbit | CD48 Antigen / BLAST1 (CD48) | Unconjugated | WB | 175 | 20 µl | P09326 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CD48 | abx691863 | Mouse CD48 Antigen / BLAST1 (CD48) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | P18181 | RUO | |
Abbexa | CD48 | abx680555 | Human CD48 Antigen / BLAST1 (CD48) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
Abbexa | CD48 | abx694234 | Human CD48 Antigen (CD48) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 400 | 20 µg | P09326 | RUO |
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