A1BG - Alpha-1-B Glycoprotein | Elisa - Clia - Antibody - Protein

Background

Alpha-1-B Glycoprotein (A1BG), also known as alpha-1B-glycoprotein, is a glycoprotein that is encoded by the A1BG gene in humans. It is synthesized in the liver with roles in immunomodulation, cell adhesion, and inflammation. Abnormalities in A1BG levels have been associated with various diseases, and it holds potential as a biomarker for diagnostic and prognostic purposes. .

Structure and Characteristics

A1BG is a plasma protein synthesized mainly by hepatocytes in the liver. It belongs to the immunoglobulin superfamily and is glycosylated, meaning it has sugar molecules attached to it, giving it a characteristic structure. The exact function of A1BG is not fully understood, but it is believed to play roles in various physiological processes, including immunomodulation, cell adhesion, and inflammation. It may also be involved in scavenging reactive oxygen species (ROS) and binding to lipophilic substances.

Clinical Significance

• A1BG levels in the blood can fluctuate under different conditions, and abnormalities in A1BG levels have been associated with various diseases and disorders. For example, changes in A1BG expression have been observed in cancer, liver disease, inflammation, and cardiovascular disorders. However, the specific mechanisms underlying these associations and whether A1BG plays a causative or reactive role in these conditions require further research.
• Due to its altered expression in certain diseases, A1BG has been explored as a potential biomarker for diagnostic and prognostic purposes. Studies have investigated its utility in various cancers, liver diseases, and inflammatory conditions as a potential indicator of disease status or treatment response.
• Although A1BG itself is not directly targeted for therapeutic interventions, understanding its roles in disease pathogenesis may lead to the development of novel therapeutic strategies. For example, drugs that modulate A1BG expression or activity could potentially be used to treat diseases associated with dysregulated A1BG levels.