Family main features
ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12) is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS12 contains several domains typical of the ADAMTS family, including a signal peptide, a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and multiple thrombospondin type 1 (TSP1) motifs. ADAMTS12 is expressed in various tissues during development and in adulthood. It is found in tissues such as the heart, lungs, kidneys, and skeletal tissues. ADAMTS12 plays a significant role in ECM remodeling by cleaving ECM proteins such as aggrecan, versican, and brevican ADAMTS12 is implicated in various aspects of tissue development, particularly in skeletal development. It is involved in processes such as chondrogenesis and osteogenesis , where it regulates ECM composition and structure. ADAMTS12 has been associated with inflammation and immune responses. It can regulate the activity of cytokines, chemokines, and growth factors, influencing immune cell recruitment, activation, and function. ADAMTS12 expression or activity may contribute to inflammatory disorders. ADAMTS12 expression levels have been found to be dysregulated in various cancers, including breast cancer, ovarian cancer, and colorectal cancer. Its roles in ECM remodeling and tissue development suggest potential contributions to tumor progression, invasion, and metastasis.Dysregulation of ADAMTS12 activity has been associated with musculoskeletal disorders such as osteoarthritis and intervertebral disc degeneration. In these conditions, ADAMTS12 contributes to the degradation of ECM components within cartilage and intervertebral discs, leading to tissue degeneration and joint dysfunction. ADAMTS12 expression levels correlate with cancer progression and poor prognosis in several types of cancer. It promotes tumor growth, invasion, and metastasis by facilitating ECM remodeling and inflammation within the tumor microenvironment.
ADAMTS12, like other ADAMTS family members, has a multi-domain structure:
ADAMTS12 is part of the ADAMTS family, which includes several members characterized by the presence of TSP1 motifs and metalloprotease domains. There are no known subtypes of ADAMTS12, but it shares structural and functional similarities with other ADAMTS proteins.
ADAMTS12 is involved in several critical biological functions:
ADAMTS12 interacts with various proteins and cellular components:
ADAMTS12 has significant implications in several clinical contexts:
ADAMTS12, a member of the ADAMTS family, is crucial for ECM remodeling, tissue development, and inflammation. It has a complex multi-domain structure, including a metalloprotease domain, disintegrin-like domain, and multiple TSP1 motifs. ADAMTS12 interacts with ECM proteins, integrins, growth factors, and thrombospondins, playing essential roles in cell migration, tissue remodeling, and various diseases. Clinically, ADAMTS12 is significant in cancer, arthritis, fibrosis, inflammatory diseases, and cardiovascular diseases. Understanding its structure, functions, interactions, and clinical implications provides valuable insights into its roles in various physiological and pathological processes.
ADAM metallopeptidase with thrombospondin type 1 motif 12(ADAMTS12)
Type 1 Motif 12,PRO4389,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 12,ADAMTS-12,ADAM-TS12
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con ADAMTS12 - ADAM metallopeptidase with thrombospondin type 1 motif 12
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Esta página contiene 13 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | ADAMTS12 | abx251962 | Human ADAM Metallopeptidase With Thrombospondin Type 1 Motif 12 (ADAMTS12) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 46.9 pg/ml | 525 | 96 tests | P58397 | RUO |
Abbexa | ADAMTS12 | abx503214 | Mouse A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | 31.2 pg/ml - 2000 pg/ml | 687.5 | 96 tests | Q811B3 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | ADAMTS12 | FNab00146 | anti- ADAMTS12 antibody | human | polyclonal | Rabbit | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | IgG | Unconjugated | ELISA, WB, IHC, IF | 100µg | P58397 | RUO | |
Abbexa | ADAMTS12 | abx301125 | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 12 (ADAMTS12) Antibody | Human | Polyclonal | Rabbit | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 12 (ADAMTS12) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | P58397 | RUO | |
Abbexa | ADAMTS12 | abx322933 | A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | P58397 | RUO | |
Abbexa | ADAMTS12 | abx375049 | A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) | Unconjugated | ELISA, IHC | 337.5 | 100 µg | P58397 | RUO | |
Abbexa | ADAMTS12 | abx104712 | A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
Abbexa | ADAMTS12 | abx230146 | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 12 (ADAMTS12) Antibody | Human | Polyclonal | Rabbit | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 12 (ADAMTS12) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | P58397 | RUO | |
Abbexa | ADAMTS12 | abx104713 | A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) Antibody | Mouse | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
Abbexa | ADAMTS12 | abx129357 | A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) Antibody | Mouse | Polyclonal | Rabbit | A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ADAMTS12 | abx065073 | Mouse A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q811B3 | RUO |
Abbexa | ADAMTS12 | abx065075 | Human A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P58397 | RUO |
Abbexa | ADAMTS12 | abx065072 | Mouse A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q8WZ42 | RUO |
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