Family main features
ADAM metallopeptidase domain 8 (ADAM8), also known as CD156a, is a member of the ADAM family of proteins, which are zinc-dependent transmembrane proteins involved in various biological processes such as cell adhesion, migration, proteolysis, and signaling. ADAM8 is primarily known for its role in inflammation, immune response, and cancer progression. ADAM8 consists of several domains, including a metalloprotease domain, a disintegrin domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and a cytoplasmic tail. These domains enable ADAM8 to participate in cell-cell and cell-matrix interactions and to proteolytically process various substrates.ADAM8 is expressed in various tissues and cell types, including leukocytes (white blood cells), lung epithelial cells, and certain cancer cells. Its expression is often upregulated in response to inflammatory stimuli, suggesting a role in immune responses.ADAM8 is implicated in the regulation of inflammation and immune responses. It has been shown to modulate leukocyte migration, cytokine production, and antigen presentation.ADAM8 can mediate cell adhesion to extracellular matrix components such as fibronectin and collagen. It also plays a role in cell migration by cleaving cell surface proteins involved in cell adhesion and signaling.ADAM8 possesses metalloprotease activity and can cleave various substrates, including cytokines, cell surface receptors, and extracellular matrix proteins. This proteolytic activity can influence cell behavior and tissue remodeling.ADAM8 has been linked to inflammatory diseases such as asthma, rheumatoid arthritis, and multiple sclerosis. It contributes to the pathogenesis of these conditions by modulating immune cell function and inflammation. ADAM8 is also overexpressed in several cancers, including breast cancer, lung cancer, and glioblastoma. Its upregulation is associated with tumor progression, invasion, metastasis, and angiogenesis. ADAM8's proteolytic activity can facilitate cancer cell migration and invasion by cleaving extracellular matrix components and cell adhesion molecules.
ADAM8 has the characteristic multi-domain structure of ADAM family proteins:
ADAM8 is classified under the ADAM family and is known for its proteolytic activity, mainly functioning as a membrane-bound protein. There are no subtypes of ADAM8, but it can exist in both membrane-bound and soluble forms.
ADAM8 is involved in several critical biological functions:
ADAM8 interacts with various proteins and cellular components:
ADAM8 has significant implications in several clinical contexts:
ADAM8, a member of the ADAM family, is crucial for proteolysis, cell adhesion, and immune responses. It has a multi-domain structure, including a metalloprotease domain for proteolytic activity and a disintegrin domain for cell adhesion. ADAM8 interacts with integrins, extracellular matrix proteins, growth factors, and immune cells. Clinically, ADAM8 is significant in asthma, arthritis, multiple sclerosis, cancer, and bone diseases. Understanding its structure, functions, interactions, and clinical implications provides valuable insights into its roles in various physiological and pathological processes.
ADAM metallopeptidase domain 8(ADAM8)
MS2,CD156,CD156A,ADAM-8
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con ADAM8 - ADAM metallopeptidase domain 8
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Esta página contiene 24 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | ADAM8 | EH0981 | Human ADAM8(Disintegrin and metalloproteinase domain-containing protein 8) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 62.5-4000pg/ml | 96T | P78325 | RUO | ||
Abbexa | ADAM8 | abx195361 | Human ADAM Metallopeptidase Domain 8 (ADAM8) CLIA Kit | Human | Serum, plasma and other biological fluids. | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 618.75 | 96 tests | RUO | ||
Abbexa | ADAM8 | abx150550 | Human ADAM Metallopeptidase Domain 8 (ADAM8) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 6.25 pg/ml - 400 pg/ml | < 2.52 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | ADAM8 | abx575909 | Human ADAM Metallopeptidase Domain 8 (ADAM8) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 62.5 pg/ml - 4000 pg/ml | 37.5 pg/ml | 525 | 96 tests | P78325 | RUO |
Abbexa | ADAM8 | abx491772 | Human ADAM Metallopeptidase Domain 8 (ADAM8) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. | Sandwich | 6.25 pg/ml - 400 pg/ml | < 2.37 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | ADAM8 | abx153595 | Mouse ADAM Metallopeptidase Domain 8 (ADAM8) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 32 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | ADAM8 | abx491773 | Mouse ADAM Metallopeptidase Domain 8 (ADAM8) CLIA Kit | Mouse | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 7.81 pg/ml - 500 pg/ml | < 3.3 pg/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | ADAM8 | FNab00144 | anti- ADAM8 antibody | human | polyclonal | Rabbit | ADAM metallopeptidase domain 8 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | P78325 | RUO | |
Abbexa | ADAM8 | abx375935 | A Disintegrin And Metalloprotease 8 (ADAM8) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloprotease 8 (ADAM8) | Unconjugated | ELISA, WB | 337.5 | 100 µg | P78325 | RUO | |
Abbexa | ADAM8 | abx335371 | A Disintegrin And Metalloprotease 8 (ADAM8) Antibody (FITC) | Human | Polyclonal | Rabbit | A Disintegrin And Metalloprotease 8 (ADAM8) | FITC | 162.5 | 20 µg | P78325 | RUO | ||
Abbexa | ADAM8 | abx128719 | A Disintegrin And Metalloprotease 8 (ADAM8) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloprotease 8 (ADAM8) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | P78325 | RUO | |
Abbexa | ADAM8 | abx171034 | A Disintegrin And Metalloprotease 8 (ADAM8) Antibody | Human | Monoclonal | Mouse | A Disintegrin And Metalloprotease 8 (ADAM8) | Unconjugated | WB, IHC, IF/ICC | 712.5 | 1 ml | RUO | ||
Abbexa | ADAM8 | abx335372 | A Disintegrin And Metalloprotease 8 (ADAM8) Antibody (Biotin) | Human | Polyclonal | Rabbit | A Disintegrin And Metalloprotease 8 (ADAM8) | Biotin | ELISA | 162.5 | 20 µg | P78325 | RUO | |
Abbexa | ADAM8 | abx027773 | ADAM Metallopeptidase Domain 8 (ADAM8) Antibody | Human | Polyclonal | Rabbit | ADAM Metallopeptidase Domain 8 (ADAM8) | Unconjugated | ELISA, WB | 281.25 | 80 µl | P78325 | RUO | |
Abbexa | ADAM8 | abx335370 | A Disintegrin And Metalloprotease 8 (ADAM8) Antibody (HRP) | Human | Polyclonal | Rabbit | A Disintegrin And Metalloprotease 8 (ADAM8) | HRP | ELISA | 162.5 | 20 µg | P78325 | RUO | |
Abbexa | ADAM8 | abx338630 | A Disintegrin And Metalloprotease 8 (ADAM8) Antibody | Human | Polyclonal | Rabbit | A Disintegrin And Metalloprotease 8 (ADAM8) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | P78325 | RUO | |
Abbexa | ADAM8 | abx230144 | ADAM Metallopeptidase Domain 8 (ADAM8) Antibody | Human | Polyclonal | Rabbit | ADAM Metallopeptidase Domain 8 (ADAM8) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | P78325 | RUO | |
Abbexa | ADAM8 | abx125491 | ADAM Metallopeptidase Domain 8 (ADAM8) Antibody | Human | Polyclonal | Rabbit | ADAM Metallopeptidase Domain 8 (ADAM8) | Unconjugated | WB | 175 | 20 µl | P78325 | RUO | |
Abbexa | ADAM8 | abx129645 | A Disintegrin And Metalloprotease 8 (ADAM8) Antibody | Mouse | Polyclonal | Rabbit | A Disintegrin And Metalloprotease 8 (ADAM8) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q05910 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ADAM8 | abx168289 | Human A Disintegrin And Metalloprotease 8 (ADAM8) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | P78325 | RUO |
FineTest | ADAM8 | P2002 | Recombinant Human ADAM8 | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | P78325 | RUO | ||
Abbexa | ADAM8 | abx167321 | Mouse A Disintegrin And Metalloprotease 8 (ADAM8) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | ADAM8 | abx652352 | Rat A Disintegrin And Metalloprotease 8 (ADAM8) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO | |
Abbexa | ADAM8 | abx694165 | Human Disintegrin And Metalloproteinase Domain-Containing Protein 8 (ADAM8) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 400 | 20 µg | P78325 | RUO |
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