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UniQ PINP RIA

UniQ PINP RIA is a quantitative radioimmunoassay designed for the measurement of the concentration of intact aminoterminal propeptide of type I procollagen, an indicator of osteoblastic activity, in human serum. The test is intended to be used as an aid in the management of postmenopausal osteoporosis

Proveedor

Aidian

Reference

67034

Tested Applications

RIA

Reactivity

Human

Status

CE Marked

Características de producto

tested_applications
RIA
reactivity
Human
category
RIA Kits
size_1
100 test
storage
2 – 8 °C
test_range
5.0‒250 µg/l.
sensitivity
2 µg/l
detection_method
The UniQ PINP RIA kit is based on the competitive radioimmunoassay technique. A known amount of labelled PINP and an unknown amount of unlabelled PINP in the sample compete for a limited number of high affinity binding sites on the polyclonal rabbit anti-PINP antibody. A second antibody, directed against rabbit IgG and coated to kaolin particles, is used to separate the antibody-bound PINP from free PINP. The radioactivity of the bound tracer antigen is measured in a gamma counter. The amount of labelled PINP in the sample tube is inversely proportional to the amount of PINP in the sample. The concentrations in unknown samples are obtained from a calibration curve, which is based on the concurrent testing of the UniQ PINP RIA calibrators that contain 0 to 250 µg/l PINP.
assay_data
2.7 % cross-reactivity with small monomeric degradation products (col1), no cross-reactivity with PIIINP
availability
Inmediate
dry_ice
No
note
50 µl serum
reserach_area
Colágeno
background
PINP - aminoterminal propeptide of type I procollagen - is a specific type I collagen metabolite which is liberated into the blood stream during the formation of new bone. Its concentration is directly related to the rate of bone turnover. In metabolic bone diseases such as osteoporosis, PINP is a sensitive indicator for identifying patients with a high rate of bone turnover and, consequently, at high risk of fracture. PINP is a useful parameter for monitoring the effectiveness of anti-resorptive and anabolic treatment.