proveedor
FineTestreference
P4508Tested Applications
Western Blot,ELISAreactivity
status
RUOclonality
Background
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL). Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor that control the activity of protein C (anticoagulant). SERPINA5 binds glycosaminoglycans, phospholipids, and retinoic acid. Glycosaminoglycans and certain phospholipids can modulate its inhibitory activity and specificity.
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). El inhibidor de la proteína C (PCI, SERPINA5) es un inhibidor de la serina proteasa que controla la actividad de la proteína C (anticoagulante). SERPINA5 se une a los glucosaminoglicanos, los fosfolípidos y el ácido retinoico. Los glucosaminoglicanos y ciertos fosfolípidos pueden modular su actividad inhibidora y su especificidad.
Características del producto
alias
Acrosomal serine protease inhibitor, IPSP, IPSP_HUMAN, PAI 3, PAI-3, PAI3, PCI, PCI-B, PLANH 3, PLANH3, Plasma serine protease inhibitor, Plasminogen activator inhibitor 3, Plasminogen activator inhibitor III, PROCI, Protein C inhibitor, Serpin A5, Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 5, Serpin peptidase inhibitor clade A member 5, Serpina5
availability
3-4 weeks
buffer
Reconstitute with Sterile distilled water
category
Proteins and Peptides
expression
Recombinant
form
Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4
host
E.Coli
immunogen target
20-406
note
This product is for research use only.
observerd MW
42.5 kDa
origin
Human
purity
Greater than 95% by SDS-PAGE gel analyses
purification
His tag
size 1
50μg
size 2
200μg
size 3
1mg
status
RUO
storage
-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
uniprot id
P05154
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