proveedor
Abbexareference
abx229359Tested Applications
FCMreactivity
Humanstatus
RUOclonality
MonoclonalDescripción
Interleukin 17A (IL17A) Antibody (APC) is a Human Monoclonal Antibody against Interleukin 17A (IL17A).
Background
The Interleukin 17 family is a group of pro-inflammatory cystine knot cytokines primarily produced by T helper 17 cells in response to stimulation with IL-23. IL17A, was previously known in rodents as CTLA8. In humans, The IL-17 family includes IL17A (sometimes referred to as "IL-17"), IL17B, IL17C, IL17D, IL17E (also known as IL-25), and IL17F. One of the most prominent roles of IL-17 is its participation in initiating and mediating proinflammatory responses. IL-17 is commonly associated with allergic reactions and can induce the production of various other cytokines (such as IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), chemokines (including IL-8, GRO-α, and MCP-1), and prostaglandins (e.g., PGE2) from different cell types, including fibroblasts, endothelial cells, epithelial cells, keratinocytes, and macrophages
La familia interleucina 17 es un grupo de citocinas proinflamatorias del nudo de cistina ( 3 S_S ), producidas principalmente por células T Helper 17 en respuesta a la estimulación con IL-23. IL17A, se conocía anteriormente en roedores como CTLA8. En humanos, la familia IL-17 incluye IL17A (a veces denominada "IL-17"), IL17B, IL17C, IL17D, IL17E (también conocida como IL-25) e IL17F. Una de las funciones más destacadas de la IL-17 es su participación en el inicio y la mediación de respuestas proinflamatorias. La IL-17 se asocia comúnmente con reacciones alérgicas y puede inducir la producción de otras citoquinas (como IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), quimiocinas (incluida IL -8, GRO-α y MCP-1) y prostaglandinas (p. ej., PGE2) de diferentes tipos de células, incluidos fibroblastos, células endoteliales, células epiteliales, queratinocitos y macrófagos.
Características del producto
assay data
Excitation/Emission: 651/660Laser line: 647
availability
Shipped within 5-15 working days.
buffer
PBS with 0.05% Proclin300, 1% BSA.
category
Primary Antibodies
clonality
Monoclonal
conjugation
APC
dry ice
No
gene id
3605
host
Mouse
immunogen target
Interleukin 17A (IL17A)
isotype
IgG1 Kappa
note
This product is for research use only.
size 1
20 tests
size 2
100 tests
size 3
200 tests
status
RUO
storage
Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze.
uniprot id
Q16552
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