Human Renin (REN) CLIA Kit

CLIA

Human

CLIA Kits

Renin

96 tests

5 × 96 tests

10 × 96 tests

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

5.49 pg/ml - 4000 pg/ml

< 2.24 pg/ml

Chemiluminescent

Sandwich

Quantitative

Shipped within 5-7 working days.

No

This product is for research use only.

The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.

Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Renin (REN, also known as angiotensinogen, not to be confused with rennin) is a protein that functions both as an enzyme and as a hormone. It is secreted as prorenin, which is inactive until another enzyme (potentially Cathepsin B) removes the inhibiting peptide. Renin catalyses the hydrolysis of angiotensinogen to angiotensin 1, which can then be hydrolysed by angiotensin-converting enzyme to stimulate vasoconstriction. When bound to the renin receptor (ATP6AP2), renin has increased catalytic activity and stimulates the ERK and p38 pathways, which increases the production of cyclooxygenase 2. Hypertension can occur as a result of abnormally high renin activity levels, and may be indicative of kidney cancer, while mutations in the gene are linked to reduced kidney function and development. Target