Human Hyaluronidase 1 (HYAL1) CLIA Kit
737,50€ (96 tests)
Características de producto
Immunogen / Target
Hyaluronidase 1 (HYAL1)
5 × 96 tests
10 × 96 tests
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
0.69 ng/ml - 500 ng/ml
< 0.28 ng/ml
Shipped within 5-7 working days.
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Hyaluronidase 1 (HYAL1) is an enzyme that hydrolyses 1,4 linkages between N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA) residues in hyaluronan, a glycosaminoglycan found in extracellular matrix. HYAL1 is expressed in the lysosomes of various tissues and is also secreted in plasma. The catalytic activity of HYAL1 is carried out by an aspartate and a glutamate residue in close proximity to each other, but also requires a distant tyrosine and asparagine residue to ensure correct binding to hyaluronan. Overexpression of HYAL1 occurs in some metastatic cancers, while mutations in the gene that reduce its catalytic activity can cause mucopolysaccharidosis IX, resulting in short stature and high serum hyaluronic acid concentrations. Target