Human Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit
618,75€ (96 tests)
Human Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit is a CLIA kit against Advanced Glycosylation End Product Specific Receptor (AGER).
Características de producto
Immunogen / Target
Advanced Glycosylation End Product Specific Receptor (AGER)
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
15.6 pg/ml - 1000 pg/ml
Shipped within 5-12 working days.
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
RAGE (receptor for advanced glycation endproducts), also called AGER, is a 35 kilodalton transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. Its name comes from its ability to bind advanced glycation endproducts (AGE), which include chiefly glycoproteins, the glycans of which have been modified non-enzymatically through the Maillard reaction. In view of its inflammatory function in innate immunity and its ability to detect a class of ligands through a common structural motif, RAGE is often referred to as a pattern recognition receptor. RAGE also has at least one other agonistic ligand: high mobility group protein B1 (HMGB1). HMGB1 is an intracellular DNA-binding protein important in chromatin remodeling which can be released by necrotic cells passively, and by active secretion from macrophages, natural killer cells, and dendritic cells. Target