DNA Polymerase Iota (POLI) Antibody (Biotin)
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Description
POLI Antibody (Biotin) is a Rabbit Polyclonal against POLI.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DNA Polymerase Iota (POLI) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UNA4 |
| Gene ID | 11201 |
| Background | Antibody anti-POLI |
| Status | RUO |
Descripción
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POLI antibody
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
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DNA Polymerase Iota (POLI) Antibody
POLI Antibody is a Rabbit Polyclonal antibody against POLI. Mammalian Polymerase iota (POL ι or POLI) owns an unusual combination of properties: it is stimulated by Mn2+ ions, can bypass some DNA lesions and misincorporates "G" opposite template "T" more frequently than incorporates the correct "A". [PMID:21304950] It also was shown to possess dRP lyase activity. In addition, POLI is much more efficient in the presence of Mn2+ in comparison to Mg2+. [PMID: 17609217]. It has been proposed that POLI involves in immunoglobulin somatic hypermutation (SHM), bypass of deaminated cytosines, several adducts of the purine bases. DNA strand crosslinks and is involved in DNA repair under oxidative stress. [PMID:15199127].
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