KAZALD1 - Kazal type serine peptidase inhibitor domain 1 | Elisa - Clia - Antibody - Protein
Family main features
Background
KAZALD1, also known as Kazal-type serine peptidase inhibitor domain 1, is a protein encoded by the KAZALD1 gene in humans. This protein belongs to the Kazal family of serine protease inhibitors, which are characterized by their ability to inhibit serine proteases, enzymes that play critical roles in various physiological processes including digestion, coagulation, immune response, and cellular signaling. The Kazal family is named after Alexander Kazal, who first described these types of inhibitors.
KAZALD1 has attracted interest in scientific research due to its potential role in various biological processes and diseases. Its expression has been observed in different tissues, suggesting that it may have diverse functions. Research into KAZALD1 is ongoing, with studies exploring its role in cancer, inflammation, and other conditions. Understanding KAZALD1's structure and function can provide insights into its biological significance and potential therapeutic applications.
Protein Structure
KAZALD1 contains a Kazal domain, which is a type of serine protease inhibitor domain. The structure of the Kazal domain typically includes a series of conserved cysteine residues that form disulfide bonds, creating a stable and compact structure. This domain interacts with the active site of serine proteases, inhibiting their activity. The primary structure of KAZALD1 includes:
- Signal Peptide: A short sequence at the N-terminus that directs the protein to the secretory pathway.
- Kazal Domain: The functional domain responsible for protease inhibition. This domain includes conserved cysteine residues that form disulfide bonds, contributing to its stability and inhibitory activity.
- Disulfide Bonds: These bonds are critical for the structural integrity of the Kazal domain, stabilizing the protein and enabling it to bind effectively to serine proteases.
The presence of these structural features allows KAZALD1 to interact with and inhibit specific serine proteases, thereby regulating their activity in various biological processes.
Classification and Subtypes
KAZALD1 is a member of the broader Kazal-type serine protease inhibitors family. Members of this family are typically classified based on their sequence homology, structural characteristics, and inhibitory profiles. While KAZALD1 itself does not have well-defined subtypes, it shares common features with other Kazal-type inhibitors, such as:
- Pancreatic Secretory Trypsin Inhibitor (PSTI): A well-known Kazal-type inhibitor involved in regulating digestive enzymes.
- Ovoinhibitor: Another Kazal-type inhibitor found in egg whites, which inhibits multiple proteases.
These inhibitors are characterized by their ability to form stable complexes with serine proteases, preventing their enzymatic activity.
Function and Biological Significance
KAZALD1's primary function is to inhibit serine proteases, which are enzymes that cleave peptide bonds in proteins. Serine proteases are involved in numerous physiological processes, including:
- Digestion: Serine proteases such as trypsin and chymotrypsin break down dietary proteins in the digestive tract.
- Blood Coagulation: Proteases like thrombin play key roles in the blood clotting cascade.
- Immune Response: Proteases such as neutrophil elastase are involved in the body's defense mechanisms.
By inhibiting these proteases, KAZALD1 can regulate their activity and influence various biological processes. Emerging research suggests that KAZALD1 may also play roles in cellular signaling, tissue remodeling, and inflammation.
Clinical Issues
Alterations in KAZALD1 expression or function have been implicated in several diseases and conditions:
- Cancer: Changes in KAZALD1 expression have been observed in various cancers. For example, overexpression of KAZALD1 has been linked to poor prognosis in certain types of cancer, suggesting it may play a role in tumor progression and metastasis.
- Inflammation: Given its role in inhibiting proteases involved in the immune response, dysregulation of KAZALD1 may contribute to inflammatory conditions. Studies have shown altered KAZALD1 levels in diseases such as rheumatoid arthritis and inflammatory bowel disease.
- Fibrosis: Protease inhibitors, including KAZALD1, can influence tissue remodeling and fibrosis. Abnormal KAZALD1 activity may be involved in fibrotic diseases, where excessive tissue scarring occurs.
Understanding the clinical implications of KAZALD1 is critical for developing potential therapeutic strategies targeting its activity.
Summary
KAZALD1, a Kazal-type serine peptidase inhibitor, is a protein with significant roles in regulating serine protease activity. Its structure, characterized by the Kazal domain with conserved cysteine residues and disulfide bonds, allows it to inhibit proteases involved in critical biological processes. Research into KAZALD1 highlights its potential involvement in various diseases, including cancer, inflammation, and fibrosis. Understanding KAZALD1's function and regulatory mechanisms can provide valuable insights into its biological significance and therapeutic potential. Continued research is essential to uncover the full spectrum of KAZALD1's roles and its implications in health and disease.
KAZALD1 Recommended name:
Kazal type serine peptidase inhibitor domain 1 (KAZALD1)
Aliases for KAZALD1
BONO1,FKSG28,FKSG40,IGFBP-rP10,
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con KAZALD1 - Kazal type serine peptidase inhibitor domain 1
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Esta página contiene 8 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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immunoassays
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | KAZALD1 | abx152099 | Human Kazal Type Serine Protease Inhibitor Domain Containing Protein 1 (KAZALD1) ELISA Kit | Human | Tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 715 | 96 tests | RUO | |
Abbexa | KAZALD1 | abx495951 | Human Kazal Type Serine Protease Inhibitor Domain Containing Protein 1 (KAZALD1) CLIA Kit | Human | Tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.115 ng/ml | 845 | 96 tests | RUO | |
Abbexa | KAZALD1 | abx529402 | Mouse Kazal-type serine protease inhibitor domain-containing protein 1 (KAZALD1) ELISA Kit | Mouse | Serum, plasma and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | Q8BJ66 | RUO |
Primary Antibodies
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | KAZALD1 | FNab04472 | anti- KAZALD1 antibody | human | polyclonal | Rabbit | Kazal-type serine peptidase inhibitor domain 1 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q96I82 | RUO | |
Abbexa | KAZALD1 | abx173239 | Kazal Type Serine Protease Inhibitor Domain Containing Protein 1 (KAZALD1) Antibody | Human | Monoclonal | Mouse | Kazal Type Serine Protease Inhibitor Domain Containing Protein 1 (KAZALD1) | Unconjugated | WB, IHC, IF/ICC | 875 | 1 ml | RUO | ||
Abbexa | KAZALD1 | abx234472 | Kazal Type Serine Protease Inhibitor Domain Containing Protein 1 (KAZALD1) Antibody | Human | Polyclonal | Rabbit | Kazal Type Serine Protease Inhibitor Domain Containing Protein 1 (KAZALD1) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q96I82 | RUO | |
Abbexa | KAZALD1 | abx129286 | Kazal Type Serine Protease Inhibitor Domain Containing Protein 1 (KAZALD1) Antibody | Human | Polyclonal | Rabbit | Kazal Type Serine Protease Inhibitor Domain Containing Protein 1 (KAZALD1) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | Q96I82 | RUO |
Proteins and Peptides
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | KAZALD1 | abx166238 | Human Kazal Type Serine Protease Inhibitor Domain Containing Protein 1 (KAZALD1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q96I82 | RUO |
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